Microsoft PowerPoint - 2019-06-28_BfR_MEAL_study_Lindtner_Lissabon.pptx
Dieses Dokument ist Teil der Anfrage „Zwischenergebnisse und Empfehlungen der BfR-MEAL-Studie“
1/9/2020 TDS framework in a food-related monitoring system - The German BfR MEAL Study O. Lindtner, I. Sarvan, A. Kolbaum, M. Greiner Bundesinstitut für Risikobewertung German food monitoring In the responsibility of the Federal States Coordinated by the Federal Office of Consumer Protection and Food Safety (BVL) Aim: − to avoid overestimation by random sampling of food instead of other risk oriented food surveillance programs − to assess proportion exceeding maximum limits − to derive mean concentration in food for chronic exposure assessment − to derive high concentrations in food for chronic or acute exposure assessment Two parts: systematic and project monitoring Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 2 1
1/9/2020 Food Monitoring in Germany Systematic Monitoring Project Monitoring • ca. 20-40 foods per year from a • Focus on specific questions pre-defined food basket • Annual selection based on • Food basket proposals of federal states, ministries, BVL* and BfR • Derived from consumption surveys • ca. 200 samples per project • Minimum of 90% of mean • Possibility to analyse diverse consumption substances, e.g. currently tropane alkaloids in baby food; • Each food item is analysed antibiotics in veal. every 3 to 6 years • Analysis of raw or processed foods (“as purchased”) * BVL: Federal Office of Consumer Protection and Food Safety Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 3 German Food Monitoring 2017 8,047 food samples − 45 different foods in the systematic monitoring − 6 projects in the project monitoring with 1.041 samples in total Cycle of 6 years to cover >90% of the diet Each product is analysed for a predefined set of residues or contaminants to close data gaps for risk assessment − Residues of plant protection products − Elements, like heavy metals − Nitrate − Mycotoxins − Other organic contaminants (dioxins, PCB, PFC, PAH) Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 4 2
1/9/2020 Importance of the German Monitoring data in the European context EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain), 2015. Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water. EFSA Journal 2015;13(2):4002, 202 pp. Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 5 Example for substances where a refined assessment is needed 8 Cd intake PTWI, JECFA 7 6 5 4 [µg/kg bodyweight per week] 3 TWI, EFSA 2 1 0 Total population vegetarians 14-18 years Mean consumer High consumers of cereals and vegetables TWI, EFSA PTWI, JECFA Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 6 3
1/9/2020 Limitations of food monitoring in Germany for exposure assessment: Example Cadmium Beverages, Eggs, meat Milk and milk Cd-ML products, others 0.2-1.0 without ML for Cd Fruits and Meat Meat vegetables Cd- Cd-ML 0.005-1.0 ML 0,005 ML 0.005 - 0.02 Water Cd-ML 0.003 - 0.005 Cereals Cd- ML 0.1 - 0.2 Fish and seafood Cd-ML 0.005 - 1.0 Contribution of regulated foods compared to foods without ML • 61 % of the mean dietary exposure is caused by regulated food items • 39 % by non-regulated food groups like milk, eggs, beverages Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 7 Substances without incomplete number of analysed foods in the German Food Monitoring • Processing contaminants (e.g. acrylamide, 3-MCPD) • Food additives, flavourings • Substances migrating from packaging material Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 8 4
1/9/2020 Example of substances where a refined assessment is needed: Lead exposure 2,0 Margin of exposure for BMDL10 for chronic kidney disease 1,8 However, individual population 1,6 groups and high consumers reach and/or exceed the 1,4 toxicological reference values for the daily intake amounts. 1,2 1,0 A weekly intake of 5 µg/kg body weight was estimated for high 0,8 consumers that exceeds the 0,6 benchmark dose for renal toxic effects for the weekly lead intake. 0,4 0,2 0,0 lower bound medium bound upper bound Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 9 Summary of limitations of the food Monitoring in Germany with regard to exposure assessment I. Mainly substances with maximum levels II. Mainly foods with maximum levels III. Mainly foods at raw agricultural commodity level IV. LOD/ LOQ as low as needed to check maximum levels V. Only partly representative Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 10 5
1/9/2020 Check of *FM: N=119, TDS: N=25; **FM: N=108, TDS: compliance of maximum levels N=24 FM: 34% (n=41) TDS: 8% (n=2) 1) What is the objective of the Analysis of exposure assessment?* trends Acute exposure FM: 3% (n=4) TDS: 40% (n=10) assessment FM: 8% (n=10) TDS: 0% (n=0) Chronic exposure assessment FM: 91% (n=108) TDS: 96% (n=24) Assessment of high percentiles of chronic exposure FM: 7% (n=8) TDS: 0% (n=0) 2) What is the objective of the chronic exposure assessment?** Refinement of known high chronic exposure FM: 8% (n=10) TDS: 0% (n=0) Assessment of mean chronic exposure FM: 100% TDS: 100% (n=108) (n=24) Analyzing of 3) What is the focus regarding Analyzing of the analyzed foods?** raw or processed foods foods prepared as consumed FM: 98% (n=106) TDS: 0% (n=0) a) Processing state FM: 6% (n=7) TDS: 100% (n=24) b) Food selection Examination of Examination of a food basket a single food or food group representative for whole diet FM: 69% (n=75) TDS: 0% (n=0) FM: 8% (n=9) TDS: 79% (n=19) Examination of a food basket not representative for whole diet Food monitoring (FM) data are more FM: 22% (n=24) TDS: 21% (n=5) Total diet study (TDS) data are more used used O7.4 Develop an exposure assessment approach combining benefits from TDS and food monitoring data Flow Chart – Combination of TDS and Food monitoring data in a „combined food control“ approach Refined TDS (Screening) TDS Refinement of existing data Formation of data base • Data refinement • Chronic exposure • Priority setting for further actions • Representative for whole diet • food prepared „as consumed“ Food Monitoring (FM) • High analytical sensitivity Complement data • Cost-effective • Acute exposure • More variability ML: Maximum Limit Continuous Monitoring ADI: Acceptable daily Intake Using FM/TDS data for food control r Benefits of TDS and/or FM Benefits of TDS data Benefits of FM data data for implementation of for implementation of FM for implementation of TDS Food Surveillance • reduction of substance • TDS-like approach instead of • targeted surveillance of food number full TDS with high concentration in • reduction of food groups • identification of less mean • targeted identification for consumed but high on risk • focus on food with high total reasons of variability food intake (ML exceeding leads to • identification of food groups ADI exceedance) for pooling Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 12 6
1/9/2020 Combine Food Monitoring and TDS Food Monitoring Total Diet Study (TDS) • foods „as purchased“ / raw • Foods „as consumed“ • Lower analytical sensitivity • Higher analytical sensitivity • Analysis of single food • Composite samples (more items (more cost-intensive) cost-effective) • Acute or chronic exposure • Chronic exposure assessment assessment VARIABILITY REPRESENTATIVENESS Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 13 Mahlzeiten für die Expositionsschätzung und Analytik von Lebensmitteln Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 14 7
1/9/2020 Modular structure of the BfR MEAL Study Plant protection Perfluorated Process contaminants product residues tensides Food contact CORE MODULE materials Elements and environmental Processing Mycotoxines contaminants Nutrients Pharmacologically active substances Food Food packaging additives Authorisation Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 15 Steps of the BfR MEAL Study Step Step11 Step 2 Step 3 Step 4 Step 5 Step 6 Selection of Shopping Preparation Pooling and Analysis Analysi Evaluation foods on national and homogenisa homogeni- s and exposure level processing tion sation assessment Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Page 16 8
1/9/2020 100s BfR http://www.bfr-meal-studie.de/en/meal-homepage.html Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 17 Challenge How to get representative pooled samples Consumption Market data surveys Market data Food Where German Marketconsumers buyCountry their food? Recipe list Specification of foods bought share of origin books Most sold recipedatabooks Household Surveys Most visited cooking homepages Kitchen utensils Out of home (telephone survey; N= 1000) consumption Preparation of foods Kitchen Kitchen (telephone Browning survey; N =preparation 1000) Out-of-Home consumption utensils (online survey, N = 2000) Degree of browning Household (online survey, N = 2000) surveys Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 18 9
1/9/2020 First fieldphase of the BfR MEAL study - Shopping 27.416 km national shopping (Berlin) 91.027 km regional shopping Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 19 First fieldphase of the BfR MEAL study – Kitchen preparation 9.351 recipes prepared Oliver Lindtner, 28.06.2019, Presentation of the Portugese TDS, Lissabon Seite 20 10
